CBD (City Centre). The grid puts laneways, theatres, and free tram travel at your door. Best for first-timers who want everything walkable. Good for: First-timers, walkability.
Southbank. Riverfront high-rises beside the arts precinct, casino, and promenade dining. Great skyline views and easy access to the NGV and concert halls. Good for: Views, arts.
Fitzroy. Melbourne's bohemian inner north, all vintage shops, live-music pubs, and Brunswick Street cafes. Choose it for indie character and nightlife. Good for: Hipsters, nightlife.
St Kilda. A bayside address with beach, Luna Park, and cake shops, a tram ride from town. Livelier and cheaper than the centre. Good for: Beach, budget.
Carlton. Home to Lygon Street's Italian restaurants and the Royal Exhibition Building. Leafy, walkable, and close to the university and museum. Good for: Food, families.